My Research
I am conducting research on epigenetics. Epigenetics refers to the study of the change in gene expression or cellular phenotype inherited even after cell division without changing the DNA base sequence. Among them, I am doing two studies. The first is a study to change the expression level by destroying a part of the gene in yeast and clarify the role of the gene from the change. A gene-disrupted strain is a yeast strain in which a desired gene to be disrupted is recombined with a drug resistance gene by homologous recombination in yeast. Also, for further consideration it is necessary to make a number of destroyed strains, not just one destroyed strain. By doing this, we can examine which genes play a role. In addition, a strain that has destroyed two specific genes from one gene is also required. By doing this, we can investigate the relationship with other genes.Regarding this research, there is little that has been elucidated yet, and it is considered that the application of the theory will benefit higher organisms such as humans if its role in eukaryotes called yeast is clarified. It is thought that this mechanism elucidates the disease caused by the change of DNA sequence, and it can be applied for prevention and treatment.
The second one is conducting research on the search for radioresistance genes. In this research, when irradiating yeast with radiation, surviving individuals and dead individuals appear, and it is done for the purpose of discovering causative genes. Elucidation of the necessity for the system of radiation resistance genes will be a new consideration of the Gene Research Group. In order to discover radiation tolerance genes, it is necessary to irradiate yeast directly. Past findings indicate that some of the genes present in yeast have robust radioresistance. The problem is that surviving individuals and dead individuals appear separately from genes called sir4. Why the original yeast strain is the same, it is not known whether individuals will vary. If this resistance gene is known, it is thought that it can be applied to human beings for radiation, influence and prevention.
The second one is conducting research on the search for radioresistance genes. In this research, when irradiating yeast with radiation, surviving individuals and dead individuals appear, and it is done for the purpose of discovering causative genes. Elucidation of the necessity for the system of radiation resistance genes will be a new consideration of the Gene Research Group. In order to discover radiation tolerance genes, it is necessary to irradiate yeast directly. Past findings indicate that some of the genes present in yeast have robust radioresistance. The problem is that surviving individuals and dead individuals appear separately from genes called sir4. Why the original yeast strain is the same, it is not known whether individuals will vary. If this resistance gene is known, it is thought that it can be applied to human beings for radiation, influence and prevention.